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TRBC1-targeting antibody–drug conjugates for the treatment of T cell cancers

Nature

​Tushar D. Nichakawade, Jiaxin Ge, Brian J. Mog, Bum Seok Lee, Alexander H. Pearlman, Michael S. Hwang, Sarah R. DiNapoli, Nicolas Wyhs, Nikita Marcou, Stephanie Glavaris, Maximilian F. Konig, Sandra B. Gabelli, Evangeline Watson, Cole Sterling, Nina Wagner-Johnston, Sima Rozati, Lode Swinnen, Ephraim Fuchs, Drew M. Pardoll, Kathy Gabrielson, Nickolas Papadopoulos, Chetan Bettegowda, Kenneth W. Kinzler, Shibin Zhou, Surojit Sur, Bert Vogelstein & Suman Paul

NEDD4L intramolecular Interactions regulate its auto- and substrate NaV1.5 ubiquitination

Journal of Biological Chemistry

Katharine M. Wright, Sara Nathan, Hanjie Jiang, Wendy Xia, HyoJeon Kim, Nourdine Chakouri, Justin  N. Nwafor, Lucile Fossier, Lakshmi Srinivasan, Zan Chen, Tatiana Boronina, Jeremy Post , Suman Paul, Robert N. Cole, Manu Ben-Johny, Philip A. Cole, Sandra B. Gabelli

Hydrophobic interactions dominate the recognition of a KRAS G12V neoantigen

Nature Communications

Katharine M. Wright, Sarah R. DiNapoli, Michelle S. Miller, P. Aitana Azurmendi, Xiaowei Zhao, Zhiheng Yu, Mayukh Chakrabarti, WuXian Shi, Jacqueline Douglass, Michael S. Hwang, Emily Han-Chung Hsiue, Brian J. Mog, Alexander H. Pearlman, Suman Paul, Maximilian F. Konig, Drew M. Pardoll, Chetan Bettegowda, Nickolas Papadopoulos, Kenneth W. Kinzler, Bert Vogelstein, Shibin Zhou, Sandra B. Gabelli

Allogeneic Blood or Marrow Transplantation with High-Dose Post-transplantation Cyclophosphamide for Acute Lymphoblastic Leukemia in Patients Aged≥ 55

Transplantation and Cellular Therapy

Jonathan A Webster, Madison Reed, Hua-Ling Tsai, Alexander Ambinder, Tania Jain, Amy E Dezern, Mark J Levis, Margaret M Showel, Gabrielle T Prince, Christopher S Hourigan, Douglas E Gladstone, Javier Bolanos-Meade, Lukasz P Gondek, Gabriel Ghiaur, W Brian Dalton, Suman Paul, Ephraim J Fuchs, Christian B Gocke, Syed Abbas Ali, Carol Ann Huff, Ivan M Borrello, Lode Swinnen, Nina Wagner-Johnston, Richard F Ambinder, Leo Luznik, Ivana Gojo, B Douglas Smith, Ravi Varadhan, Richard J Jones, Philip H Imus

Allogeneic Blood or Marrow Transplantation with Post-Transplantation Cyclophosphamide for Peripheral T Cell Lymphoma: The Importance of Graft Source

Transplantation and Cellular Therapy

Cole H Sterling, Michael S Hughes, Hua-Ling Tsai, Kathryn Yarkony, Ephraim J Fuchs, Lode J Swinnen, Suman Paul, Javier Bolaños-Meade, Leo Luznik, Philip H Imus, Syed Abbas Ali, Tania Jain, Alexander Ambinder, Amy DeZern, Carol Ann Huff, Christian B Gocke, Ravi Varadhan, Nina Wagner-Johnston, Richard J Jones, Richard F Ambinder

More on CD19-CAR T Cells in Systemic Lupus Erythematosus

The New England Journal of Medicine 

Maximilian F Konig, Suman Paul

Structural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens

Nature Communications

Michael S Hwang, Michelle S Miller, Puchong Thirawatananond, Jacqueline Douglass, Katharine M Wright, Emily Han-Chung Hsiue, Brian J Mog, Tihitina Y Aytenfisu, Michael B Murphy, P Aitana Azurmendi, Andrew D Skora, Alexander H Pearlman, Suman Paul, Sarah R DiNapoli, Maximilian F Konig, Chetan Bettegowda, Drew M Pardoll, Nickolas Papadopoulos, Kenneth W Kinzler, Bert Vogelstein, Shibin Zhou, Sandra B Gabelli

Targeting loss of heterozygosity for cancer-specific immunotherapy

Proceedings of the National Academy of Sciences

Michael S Hwang, Brian J Mog, Jacqueline Douglass, Alexander H Pearlman, Emily Han-Chung Hsiue, Suman Paul, Sarah R DiNapoli, Maximilian F Konig, Drew M Pardoll, Sandra B Gabelli, Chetan Bettegowda, Nickolas Papadopoulos, Bert Vogelstein, Shibin Zhou, Kenneth W Kinzler

TCR β chain–directed bispecific antibodies for the treatment of T cell cancers

Science Translational Medicine

Suman Paul, Alexander H Pearlman, Jacqueline Douglass, Brian J Mog, Emily Han-Chung Hsiue, Michael S Hwang, Sarah R DiNapoli, Maximilian F Konig, Patrick A Brown, Katharine M Wright, Surojit Sur, Sandra B Gabelli, Yana Li, Gabriel Ghiaur, Drew M Pardoll, Nickolas Papadopoulos, Chetan Bettegowda, Kenneth W Kinzler, Shibin Zhou, Bert Vogelstein

Targeting a neoantigen derived from a common TP53 mutation

Science

Emily Han-Chung Hsiue, Katharine M Wright, Jacqueline Douglass, Michael S Hwang, Brian J Mog, Alexander H Pearlman, Suman Paul, Sarah R DiNapoli, Maximilian F Konig, Qing Wang, Annika Schaefer, Michelle S Miller, Andrew D Skora, P Aitana Azurmendi, Michael B Murphy, Qiang Liu, Evangeline Watson, Yana Li, Drew M Pardoll, Chetan Bettegowda, Nickolas Papadopoulos, Kenneth W Kinzler, Bert Vogelstein, Sandra B Gabelli, Shibin Zhou

Bispecific antibodies targeting mutant RAS neoantigensers

Science Immunology

Jacqueline Douglass, Emily Han-Chung Hsiue, Brian J Mog, Michael S Hwang, Sarah R DiNapoli, Alexander H Pearlman, Michelle S Miller, Katharine M Wright, P Aitana Azurmendi, Qing Wang, Suman Paul, Annika Schaefer, Andrew D Skora, Marco Dal Molin, Maximilian F Konig, Qiang Liu, Evangeline Watson, Yana Li, Michael B Murphy, Drew M Pardoll, Chetan Bettegowda, Nickolas Papadopoulos, Sandra B Gabelli, Kenneth W Kinzler, Bert Vogelstein, Shibin Zhou

Checkpoint blockade treatment sensitises relapsed/refractory non‐Hodgkin lymphoma to subsequent therapy

British Journal of Haematology

Nicole A Carreau, Philippe Armand, Reid W Merryman, Ranjana H Advani, Michael A Spinner, Alex F Herrera, Radhakrishnan Ramchandren, Muhammad S Hamid, Sarit Assouline, Raoul Santiago, Nina Wagner‐Johnston, Suman Paul, Jakub Svoboda, Steven M Bair, Stefan K Barta, Sunita Nathan, Reem Karmali, Pallawi Torka, Kevin David, Frederick Lansigan, Daniel Persky, James Godfrey, Julio C Chavez, Yuhe Xia, Catherine Diefenbach

CARD19, the protein formerly known as BinCARD, is a mitochondrial protein that does not regulate Bcl10-dependent NF-κB activation after TCR engagement

Cellular Immunology

Kariana E Rios, Anuj K Kashyap, Sean K Maynard, Michael Washington, Suman Paul, Brian C Schaefer

Checkpoint blockade treatment may sensitize Hodgkin lymphoma to subsequent therapy

The Oncologist

Nicole A Carreau, Orrin Pail, Philippe Armand, Reid Merryman, Ranjana H Advani, Michael A Spinner, Alex Herrera, Robert Chen, Sarah Tomassetti, Radhakrishnan Ramchandren, Muhammad S Hamid, Sarit Assouline, Raoul Santiago, Nina Wagner‐Johnston, Suman Paul, Jakub Svoboda, Steven Bair, Stefan Barta, Yang Liu, Sunita Nathan, Reem Karmali, Madelyn Burkart, Pallawi Torka, Kevin David, Catherine Wei, Frederick Lansigan, Lukas Emery, Daniel Persky, Sonali Smith, James Godfrey, Julio Chavez, Yuhe Xia, Andrea B Troxel, Catherine Diefenbach

Non-myeloablative allogeneic transplantation with post-transplant cyclophosphamide after immune checkpoint inhibition for classic Hodgkin lymphoma: a retrospective cohort study

Biology of Blood and Marrow Transplantation

Suman Paul, Marianna Zahurak, Leo Luznik, Richard F Ambinder, Ephraim J Fuchs, Javier Bolaños-Meade, Nina Wagner-Johnston, Lode J Swinnen, Laura Schoch, Ravi Varadhan, Richard J Jones, Douglas E Gladstone

Impact of treatment beyond progression with immune checkpoint blockade in Hodgkin lymphoma

The Oncologist

Reid W Merryman, Nicole A Carreau, Ranjana H Advani, Michael A Spinner, Alex F Herrera, Robert Chen, Sarah Tomassetti, Radhakrishnan Ramchandren, Muhammad Hamid, Sarit Assouline, Raoul Santiago, Nina Wagner‐Johnston, Suman Paul, Jakub Svoboda, Steven M Bair, Stefan K Barta, Yang Liu, Sunita Nathan, Reem Karmali, Madelyn Burkart, Pallawi Torka, Kevin A David, Catherine Wei, Frederick Lansigan, Lukas Emery, Daniel Persky, Sonali M Smith, James Godfrey, Julio Chavez, Jonathan B Cohen, Andrea B Troxel, Catherine Diefenbach, Philippe Armand

Allogeneic haploidentical blood or marrow transplantation with post-transplantation cyclophosphamide in chronic lymphocytic leukemia

Biology of Blood and Marrow Transplantation

Suman Paul, Hua-Ling Tsai, Patrick Lowery, Ephraim J Fuchs, Leo Luznik, Javier Bolaños-Meade, Lode J Swinnen, Satish Shanbhag, Nina Wagner-Johnston, Ravi Varadhan, Richard F Ambinder, Richard J Jones, Douglas E Gladstone

Phlegmasia cerulea dolens from radiation-induced venous stenosis

Cleveland Clinic journal of medicine

Suman Paul, Mujeeb Sheikh

Management of dabigatran-induced bleeding with continuous venovenous hemodialysis

International Journal of Hematology

Suman Paul, Danae Hamouda, Rohini Prashar, Chiamaka Mbaso, Abdur Khan, Abdulmonam Ali, Sarthi Shah, Ragheb Assaly

Metabolic Acidosis in a Patient With Isopropyl Alcohol Intoxication: A Case Report

Annals of internal medicine

Xiaomei Meng, Suman Paul, Douglas J Federman

T cell receptor signals to NF-κB are transmitted by a cytosolic p62-Bcl10-Malt1-IKK signalosome

Science Signaling

Suman Paul, Maria K Traver, Anuj K Kashyap, Michael A Washington, Joseph R Latoche, Brian C Schaefer

A new look at T cell receptor signaling to nuclear factor-κB

Trends in Immunology

Suman Paul, Brian C Schaefer

Selective autophagy of the adaptor protein Bcl10 modulates T cell receptor activation of NF-κB

Immunity

Suman Paul, Anuj K Kashyap, Wei Jia, You-Wen He, Brian C Schaefer

Selective autophagy regulates T cell activation

Autophagy

Suman Paul, Brian C Schaefer

Cutting edge: TCR ligation triggers digital activation of NF-κB

The Journal of Immunology

Lara M Kingeter, Suman Paul, Sean K Maynard, Natalia G Cartwright, Brian C Schaefer

Links

Location

1650 Orleans Street, CRB1, Room 3M90, Baltimore, MD 21287

Contacts

419-614-3900

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